Observed Data

Susan at Age 25

Susan at Age 36

[1] “This diagram is based on a survey of women with a BRCA1 or BRCA2 germline mutation—confirmed genetic predisposition to breast and ovarian cancer—from the United States, Australia, Canada, and the United Kingdom (N=598). The figure depicts sequences of women’s stated choices for cancer risk reduction treatments or procedures. The arrows are proportional to the number of patients.

Data Source: This multi-national patient-centered research was designed as a discrete-choice experiment to measure reported treatment choices of women who have a BRCA1 or BRCA2 mutation, and compare stated choices between surgical and non-surgical options for risk reduction including a hypothetical new intervention. The study (protocol 20140153) was sponsored by Amgen Inc. in collaboration with RTI Health Solutions. Although this figure is part of a publication currently under review, the study methods and primary analyses have been described elsewhere:

Footnotes: